Huntington's News

Neutrons provide first sub-nanoscale snapshots of Huntington's disease protein

Posted: 20th May 2011

Researchers at the Department of Energy's Oak Ridge National Laboratory and the University of Tennessee have for the first time successfully characterized the earliest structural formation of the disease type of the protein that causes Huntington's disease. The incurable, hereditary neurological disorder is always fatal and affects one in 10,000 Americans.

Novel mouse model provides insight into rare neurodegenerative disease

Posted: 12th May 2011

New research sheds light on common pathogenic mechanisms shared by Huntington's disease (HD) and HD-like disorders. The study, published by Cell Press in the May 12, 2011, issue of the journal Neuron, uses a new transgenic mouse model for an HD-like disorder to unravel complex molecular events that drive disease pathology.

Read more about this research.

Huntington Society "like my child," Ariel Walker says

Posted: 12th May 2011

CAMBRIDGE — Ariel Walker only knew one person with Huntington’s disease when she started a national support organization with her husband, Ralph, almost 40 years ago. Since then, the Cambridge woman got to know many people affected by the fatal neurological disease and is determined to keep working to offer support and hopefully an effective treatment. Those people are the reason she stays involved with the Canadian charity.

Read the full story on The Record.com website.

UMMS researchers develop new technology to screen and analyze genetic mutations

Posted: 14th April 2011

WORCESTER, Mass. – A single change to even one of the thousands of DNA codes that make up each gene in the human genome can result in severe diseases such as cancer, cystic fibrosis, muscular dystrophy or Huntington's Disease. A similarly minor change in the DNA of a virus or bacteria can give rise to drug resistant strains that are difficult for physicians to treat with standard drug therapies. For these reasons, scientists have long sought ways to study the effects genetic mutations can have on an organism but have been hampered in these efforts by an inability to easily and efficiently produce and analyze the thousands of potential changes possible in even one small gene.

A new study by scientists at the University of Massachusetts Medical School, published in Early Edition of the Proceedings of the National Academy of Sciences online on April 4, describes a novel technique to produce all potential individual mutations and using deep sequencing technology simultaneously analyze each change's impact on the cell.

More information on the EurekAlert! website.

UK Insurers Agree to Extend Ban on Using Genetic Tests

Posted: 14th April 2011

The Association of British Insurers announced the extension of an agreement under which the results of genetic testing will not be used to deny insurance to applicants.

The agreement, known as the Concordat and Moratorium on Genetics, will now run until 2017. It was introduced in 2001 after agreement between the industry and the U.K. Department of Health.

Like to know more? Visit insurancenewsnet.com.

Huntington's disease protein has broader effects on brain, study shows

Posted: 14th April 2011

In Huntington's disease, the mutant protein known as huntingtin leads to the degeneration of a part of the brain known as the basal ganglia, causing the motor disturbances that represent one of the most defining features of the fatal disease. But a new study reported in the April issue of Cell Metabolism, a Cell Press publication, shows that the mutant protein also is responsible for metabolic imbalances in the hypothalamus, a brain region that plays an important role in appetite control.

"This helps to explain metabolic changes and increases in appetite that have been observed in people at the early stages of disease," even before any motor symptoms appear, said Åsa Petersén of Lund University in Sweden. "It should encourage us to do more clinical studies. If we really understand the pathways that are affected, it may lead to new targets for intervention."

Read the full story on the EurekAlert! website.

Developments on the Far North Coast

Posted: 24th February 2011

I (Mark Bevan) am planning a trip to the far north coast of NSW in April this year. I will be linking up with the Queensland Association, who currently provide support to Huntington’s families in the far north of NSW, and working with them on how the NSW Association can assist in providing support to Huntington’s families in that area.

In addition to that, I will be visiting other areas on the north coast down to around the Kempsey area. The preliminary plan is to travel in the week beginning April 11, and visit as many people as possible, catch up with some Qld Association workers, meet with Huntington’s families and related health professionals near the border, and those further south, down to around Coffs Harbour and Kempsey. If you live in any of the areas I have mentioned, I would love to hear from you – you can email me mark@ahdansw.asn.au or call me on 0410 629 850.

How disordered proteins spread from cell to cell, potentially spreading disease

Posted: 24th February 2011

One bad apple is all it takes to spoil the barrel. And one misfolded protein may be all that's necessary to corrupt other proteins, forming large aggregations linked to several incurable neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's.

Stanford biology Professor Ron Kopito has shown that the mutant, misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits.

Read more on EurekAlert.

Collaboration to advance therapy for Huntington’s Disease

Posted: 28th January 2011

UMass Medical School has entered into a research collaboration with pharmaceutical company Lundbeck Inc. aimed at further development of a targeted therapy to slow or halt the progression of Huntington’s disease (HD).

Read the full story at EurekAlert.

Genetic research offers hope of improved treatment for Huntington's disease

Posted: 27th January 2011

Research led by the University of Leicester in the UK has raised hopes about possible new treatments for devastating neurodegenerative disorders such as Huntington's disease, for which there is currently no cure. The trans-Atlantic team of scientists made the discoveries using cutting-edge genetic techniques. The study was partially funded by a Marie Curie grant under the EU's Seventh Framework Programme (FP7), and has been published in The Journal of Biological Chemistry.

Read more at the European Commission CORDIS website.

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